IEEE

LMADCNV: A CNV Detection Method Based on Local Features and MAD for NGS Data

Abstract: Copy number variations (CNVs) are a type of structural variation in the genome that impact gene dosage, with significant implications for both normal phenotypic variability and ...
GitHub

Robust detection of clinically relevant structural and copy number variation from whole genome sequencing data

Microarrays have been the mainstay for detecting clinically relevant copy number variants (CNV) in patients. Whole genome sequencing (WGS) has the potential to provide far higher resolution of CNV ...
technologynetworks

Accelerate Drug Discovery With Small Molecule Microarrays

Drug discovery is a long and challenging process, often slowed by traditional screening methods. Small molecule microarrays (SMM) offer a high-throughput, efficient method to identify potential small ...
IEEE

Robust Recurrent CNV Detection in the Presence of Inter-Subject Variability

Abstract: The study of recurrent copy number variations (CNVs) plays an important role in understanding the onset and evolution of complex diseases such as cancer. Array-based comparative genomic ...
ascopubs.org

MultiChip: A new diagnostic tool to perform gene expression analysis and CNV in one array.

Targeting ER-Golgi homeostasis as a therapeutic strategy in lung cancer. Background: In the routine diagnostic of cancers, the monitoring of the transcriptome and the chromosomal abnormalities becomes ...
ahajournals.org

A Multicenter Analysis of Abnormal Chromosomal Microarray Findings in Congenital Heart Disease

Chromosomal microarray analysis (CMA) provides an opportunity to understand genetic causes of congenital heart disease (CHD). The methods for describing cardiac phenotypes in patients with CMA ...
Business Wire

New Data from Universal DX: Combining Copy Number Variation (CNV) with cfDNA Fragment Size Information Could Serve as Promising New Avenue for Early Detection of Colorectal ...

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Universal Diagnostics (Universal DX), a bioinformatics and multi-omics company on a mission to transform cancer into a curable disease, today announced the results ...
GitHub

Gene count influencing CNV detection

I am wondering how the number of genes expressed may influence the CNV detection. Indeed, as Gulati et al have noted that progenitor cell tend to have higher gene count, I am afraid to miss some CNV ...
Business Wire

Vaxxas Announces Initiation of Phase I Clinical Study of First Needle-Free COVID-19 Vaccine (HexaPro) Delivered Using High-Density Microarray Patch (HD-MAP)

Vaxxas holds an exclusive license from The University of Texas at Austin (UTA) to the SARS-CoV-2 spike subunit vaccine (HexaPro) for vaccination using a patch. HexaPro, a second-generation SARS-CoV-2 ...
technologynetworks

Genetic Testing Reveals DNA Changes in Children With Early-Onset Psychosis

While children are known for their active imaginations, it’s extremely rare for them to have true psychotic symptoms. But two unusual case studies, both of children under seven, prompted a new ...
Frontiers

Copy Number Variation Analysis of Euploid Pregnancy Loss

Objectives: Copy number variant (CNV) is believed to be the potential genetic cause of pregnancy loss. However, CNVs less than 3 Mb in euploid products of conceptions (POCs) remain largely unexplored.